Fmoc相关论文
经由 intramolecular O-to-S 酰转移的肽 thioester 准备是为通过 Fmoc 化学的蛋白质化学药品合成的一个最近发达的方法。理论计算......
以N-芴甲氧羰基-L-亮氨酸(Fmoc-Leu-OH)和N-芴甲氧羰基脯氨酸(Fmoc-Pro-OH)为原料,采用经典的Fmoc固相合成法,通过对氨基酸N端的保......
替莫瑞林醋酸盐(tesamorelin,商品名为Egrifta)由加拿大Theratechnologies公司研制,2010年11月10日经美国FDA批准在美国由EMD Sero......
本文通过直接还原N-烷基化的反应将1,3-二噻烷衍生物导入赖氨酸侧链,合成了两个保护的氨基酸络合剂N~α-Fmoc-N~ε,N~ε-di((2,2-d......
We have developed an expedient approach,“HOPE”(hybrid orthogonal protocol with ease) strategy for the synthesis of pep......
A series of v-aminoalkyl ammonium hydrogen phosphates were synthesized through a simple and efficient three-step method.......
A novel peptide designated secapin-1,was purified and characterized from Apis mellifera.The molecular weight of 25 amino......
目的:探索α-促黑激素的合成工艺。方法:采用多肽固相合成法制备α-促黑激素。以Rink amide-MBHA树脂为载体、使用Fmoc保护策略、T......
Here, we report a new strategy for rapid synthesis of branched peptide by side-chain hydrazide ligation at Asn. The hydr......
The C-terminal conjugate of ubiquitin with 7-amino-4-methylcoumarin (Ub-AMC) is an important probe for fluorescencebased......
目的:利用诱导碰撞解离串联质谱技术,获得富含半胱氨酸毒素多肽α-芋螺毒素(α-CTx)LtIA的裂解规律,为分析未知天然α-芋螺毒素肽......
Gelation capability of cysteine-modified cyclo(L-Lys-L-Lys)s dominated by Fmoc and Trt protecting gr
A series of symmetrical peptidomimetics(3–8) based on cysteine-modified cyclo(L-Lys-L-Lys)s were synthesized, and their......
通过两种不对称催化方法合成了(S)-3,5-二溴苯丙氨酸.一种方法是以二苯亚胺甘氨酸叔丁酯和3,5-二溴苄基溴为底物,在O-烯丙基-N-9-......
Recent advances in the preparation of Fmoc-SPPS-based peptide thioester and its surrogates for NCL-t
Solid phase peptide synthesis(SPPS)based on Fmoc chemistry has become a commonly used technique in peptide chemistry,as ......
As a non-specific modulator of macrophage, multiplied muramyl dipeptide (MMD) is solid-phase synthesized by application ......
为研究血管紧张素转换酶(angiotensin converting enzyme,ACE)抑制肽体外抑制ACE活性以期筛选出有降压作用的先导物,采用Fmoc固相......
A new conformationally restricted cyclic analogue of muramyl dipeptide was designed and manually synthesized by our 揗es......
引入跨股氨基酸队的方法进行β-发夹结构的设计,序列[R1G2T3F4W5V6d-P7S8V9N10Y11F12,β2]中包含二个氨基酸对V6V9和F4Y11,并以d-P......
本文报道了几种9-芴甲氧羰-氨基酸-2,4,5-三氯苯活泼酯的制法和性质.用上述活泼酯为酰化剂,并以1-羟基苯并三唑作催化剂及酸性添加......
为寻找高活性且耐酶水解的TP_5类免疫调节剂,根据TP_5的构效关系设计合成了一个三肽,二个五肽。肽链的合成采用DCC-HOBT和活化酯在......
The (β-cyclodextrin (CD) dimer bridged with aspartic acid (ASP) derivative, FITC-ASP(NH-(-CD)2 (Host, FITC=fluorescein-......
本文用Fmoc-及Boc-固相多肽合成法合成了T肽,结果表明Boc法得率略高于Fmoc法,但其纯度没有Fmoc法好。在两种合成T肽方法中,均得到......
三棕榈酰 S 甘油酰 半胱氨酸 (P3C)是一种B细胞分裂原 ,并能在体内激活细胞毒T淋巴细胞 .它是一种无毒佐剂 .对该佐剂进行了合成......
用Fmoc/But方法合成了从线纹芋螺中筛选的具有镇痛作用的芋螺多肽SO3,通过对合成中偶合方法及裂解条件的优化,提高了线性肽的合成......
本综述对十几年来固相肽合成中保护-裂解方式的发展状况,尤其以 Boc-Bz(?) 及 Fmoc-tBu 两类保护方式为主的应用特点、不断改进的......
目的 为了改善肽核酸的理化和生物学性质 ,对经典肽核酸的结构进行衍生化和修饰。方法 采用Ugi四组分缩合反应进行PNA单体的合成......
本文综述了近年来在糖肽合成方面的研究进展,主要包括三氯乙酰亚胺酯法,缩水内醚糖法,酶合成法,固相合成法及酶与固相结合法。分析......
Peptide analogs of salmon calcitonin (sCT) were synthesized by using Fmoc-based chemistry on MBHA resins Salmon calciton......
Human urotension-Ⅱwas synthesized efficiently on Wang resin under microwave irradiation using Fmoc/tBu orthogonal prote......
本文通过聚苯乙烯固载聚乙二醇氨基树脂与对羟甲基苯氧乙酸结合制备了具有酸敏手臂结构的对羟甲基苯氧乙酰胺PEG树脂（简称PS－PEG－HMPA......
The cationized 9-fluorenylmethoxycarbonyl (Fmoc) protected amino acids were analyzed by the electros-pray ionization tan......
目的:采用Fmoc固相合成法合成一种新型生长抑素类似物depreotide。方法:以Fmoc固相法合成depreotide的环肽片段部分cyclo-[(N-Me)P......
用与反相高效液相色谱偶联的串联质谱 (RPHPLC MS MS)分析一个固相化学合成的九肽H2 N Tyr Val Asn Val Asn Met Gly Leu Lys CONH......
Sincetheirintroductionin 1992byFr啨ｃｈｅｔａｎｄＳｖｅｃ[1] ,monolithicsupportsasstationaryphasesinhigh performanceliquidchromatography (HPLC......
采用叔丁氧羰基(Boc)、苄氧羰基(Z)和芴甲氧羰基(Fmoc)这3种保护基保护苯丙氨酸的氨基,顺利得到3个保护的苯丙氨酸(Ⅲa-c);保护的......
O-Phosphoryl serine derivative can perform self-catalytic esterification reaction in the mixture of CH3OH and CHCl3 at t......
Peptide nucleic acids (PNA) oligomers were synthesized in most cases by peptide synthesis from N-protected monomers. In ......
The tetrazole analogues have been synthesized from fluorenylmethoxycarbonyl (Fmoc)- protected amino acids by three steps......
Exendin-4是首个获准上市的肠促胰素类似物药物,可模拟人体自身激素GLP-1的功能,不仅改善血糖,还能促进胰岛β细胞新生、增殖,抑制......
A microwave-assisted solid phase synthesis for endothelin 1 is presented.Reduced endothelin 1 was synthesized efficientl......
Polymer Supported Synthesis of Multi-substituted Pyrimidine-4-one Derivatives via Pbf-activated Thio
Efficient polymer supported synthesis of multi-substituted pyrimidine-4-one derivatives was described. Target products w......
The first synthesis of the naturally occurring cyclic peptide euryjanicin B has been achieved.A general method was descr......
三价有机砷化合物以其潜在的抗肿瘤活性正在引起药物化学家的兴趣。本文中合成了一组在侧链上引入1-砷-2,6,7-三硫二环(2,2,2)辛烷......
<正>2017年1月19日,由Synergy Pharmas公司研发的plecanatide经FDA批准上市,商品名为Trulance。该药用于治疗成年患者慢性特发性便......
